Is our One Great Love provided by destiny or do we get to choose? One Great Love tackles about love, which remains to be one of the greatest mysteries up to this day. Falling in love with someone is one thing, but staying in love with that person is another story. This is a love story of Zyra Paez, a woman fortunate enough to know and be with her one great love. Carl Mauricio, Carl’s turbulent past has left a scarred, and in the process, keeps hurting the woman who did nothing but love him over anything else. And Dr. Ian Arcano, a heart doctor who firmly believes in the sanctity of family and keeping it that way. Ian is a dependable friend to Zyra, but then eventually falls in love with her. The lives of Zyra, Carl, and Ian are intertwined with one another in a story that reveals to us that like every human being, we all seek for love, but our views about One Great Love.
College sweethearts Christine and Raf meet again for the first time, eight years after their breakup. Christine, who once was an over-achieving art student, has become a failure while Raf, a guy nobody thought would be a great man, is now an esteemed doctor to the barrios. As both now live a life different from each other, their reunion takes them back to their youth and the dreams they shared back in the day. From then on, familiar feelings start to resurface and they find themselves falling in love with each other again. Will they both be willing to risk what they currently have just to feel the bliss of being young again?